STAB2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comSTAB2 Polyclonal Antibody for Human(Homo sapiens)

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STAB2 (Gene name),

Stabilin-2 (Protein name ), STAB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

STAB2(FEEL2;FELL;FEX2;HARE);

Protein name:

Stabilin-2;

Alternative:

Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2(FEEL-2);FAS1 EGF-like and X-link domain-containing adhesion molecule 2;Hyaluronan receptor for endocytosis;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with GULP1 and heparin. Also interacts with alpha-M/beta-2 integrin (ITGAM and ITGB2) and thymosin beta 4 (TMSB4X and/or TMSB4Y).

Function:

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cytoplasm Only a small amount appears to be present at the cell surface.

Protein Attributes:

Sequence length:

2551

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3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.408249

Pfam:

PF12947

STRING:

9606.ENSP00000373539

Pfam:

PF02469

MIM:

608561

String:

Q8WWQ8

SMR:

Q8WWQ8

KEGG:

hsa:55576

Uniprot:

Q8WWQ8

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ELISA Kit for Human Stabilin-2

Cat.:

E0466r

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96T

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ELISA Kit for Human Stabilin-2

Cat.:

E0466h

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96T

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ELISA Kit for Human Stabilin-2

Cat.:

E0466m

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Packing:

96T

CLIA Kit for Human Stabilin-2

Cat.:

U0466r

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Packing:

96T

CLIA Kit for Human Stabilin-2

Cat.:

U0466h

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MSDS:

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Packing:

96T

CLIA Kit for Human Stabilin-2

Cat.:

U0466m

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Packing:

96T

Polyclonal Antibody for Human Stabilin-2

Cat.:

P0466Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Stabilin-2

Cat.:

P0466Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Stabilin-2

Cat.:

P0466Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Stabilin-2

Protein for Human Stabilin-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues."
Politz O. , Gratchev A. , McCourt P.A.G. , Schledzewski K. , Guillot P. , Johansson S. , Svineng G. , Franke P. , Kannicht C. , Kzhyshkowska J. , Longati P. , Velten F.W. , Johansson S. , Goerdt S.
Biochem. J.362:155-164(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT HIS-510
2.

"FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities."
Adachi H. , Tsujimoto M.
J. Biol. Chem.277:34264-34270(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;VARIANT HIS-510
3.

"FEX2, a novel cell adhesion molecule of Fas-1 superfamily mediates cell-cell interaction."
Park S.-Y. , Kim I.-S.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-2551;VARIANT THR-2039
tissue: Spleen.
5.

"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H. , Takano J. , Nomura N. , Kikuno R. , Nagase T. , Ohara O.
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-2551;VARIANTS THR-2039 AND VAL-2401
tissue: Spleen.
6.

"Purification and molecular identification of the human hyaluronan receptor for endocytosis."
Zhou B. , McGary C.T. , Weigel J.A. , Saxena A. , Weigel P.H.
Glycobiology13:339-349(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1136-2551;PROTEIN SEQUENCE OF 1136-1144; 1257-1269; 1597-1605; 1623-1645; 1652-1660; 1813-1817; 1834-1843; 1914-1918; 1953-1957; 2204-2217; 2211-2215 AND 2355-2367;TISSUE SPECIFICITY
7.

"Molecular cloning and characterization of human FELL sharing homology with CD44."
Tao Q. , Zhang W. , Cao X.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1599-2551;VARIANT VAL-2401
8.

"Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)."
Harris E.N. , Kyosseva S.V. , Weigel J.A. , Weigel P.H.
J. Biol. Chem.282:2785-2797(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1136-1144;GLYCOSYLATION;SUBCELLULAR LOCATION;FUNCTION
9.

"FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products."
Tamura Y. , Adachi H. , Osuga J. , Ohashi K. , Yahagi N. , Sekiya M. , Okazaki H. , Tomita S. , Iizuka Y. , Shimano H. , Nagai R. , Kimura S. , Tsujimoto M. , Ishibashi S.
J. Biol. Chem.278:12613-12617(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
10.

"Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)."
Harris E.N. , Weigel J.A. , Weigel P.H.
J. Biol. Chem.279:36201-36209(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding."
Hansen B. , Longati P. , Elvevold K. , Nedredal G.-I. , Schledzewski K. , Olsen R. , Falkowski M. , Kzhyshkowska J. , Carlsson F. , Johansson S. , Smedsroed B. , Goerdt S. , Johansson S. , McCourt P.
Exp. Cell Res.303:160-173(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Stabilin-2 is involved in lymphocyte adhesion to the hepatic sinusoidal endothelium via the interaction with alphaMbeta2 integrin."
Jung M.Y. , Park S.Y. , Kim I.S.
J. Leukoc. Biol.82:1156-1165(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH ALPHA-M/BETA-2 [ITGAM/ITGB2] INTEGRIN
13.

Jung M.Y. , Park S.Y. , Kim I.S.
J. Leukoc. Biol.83:438-438(2008)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
14.

"Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor."
Park S.Y. , Jung M.Y. , Kim H.J. , Lee S.J. , Kim S.Y. , Lee B.H. , Kwon T.H. , Park R.W. , Kim I.S.
Cell Death Differ.15:192-201(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
15.

"Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment."
Lee S.J. , So I.S. , Park S.Y. , Kim I.S.
FEBS Lett.582:2161-2166(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMSB4X
16.

"Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment."
Park S.Y. , Kang K.B. , Thapa N. , Kim S.Y. , Lee S.J. , Kim I.S.
J. Biol. Chem.283:10593-10600(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GULP1
17.

"The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin."
Harris E.N. , Weigel J.A. , Weigel P.H.
J. Biol. Chem.283:17341-17350(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance."
Park S.-Y. , Kim S.-Y. , Jung M.-Y. , Bae D.-J. , Kim I.-S.
Mol. Cell. Biol.28:5288-5298(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins."
Harris E.N. , Baggenstoss B.A. , Weigel P.H.
Am. J. Physiol.296:G1191-G1199(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1743
tissue: Liver.

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